diff --git a/InvenTree/stock/admin.py b/InvenTree/stock/admin.py
index 5f1b134966..abd3db20cb 100644
--- a/InvenTree/stock/admin.py
+++ b/InvenTree/stock/admin.py
@@ -117,6 +117,8 @@ class StockItemResource(ModelResource):
         exclude = [
             # Exclude MPTT internal model fields
             'lft', 'rght', 'tree_id', 'level',
+            # Exclude internal fields
+            'serial_int',
         ]
 
 
diff --git a/InvenTree/stock/api.py b/InvenTree/stock/api.py
index e287441382..2ffc2e8d69 100644
--- a/InvenTree/stock/api.py
+++ b/InvenTree/stock/api.py
@@ -876,6 +876,7 @@ class StockList(generics.ListCreateAPIView):
 
     ordering_field_aliases = {
         'SKU': 'supplier_part__SKU',
+        'stock': ['quantity', 'serial_int', 'serial'],
     }
 
     ordering_fields = [
@@ -887,6 +888,7 @@ class StockList(generics.ListCreateAPIView):
         'stocktake_date',
         'expiry_date',
         'quantity',
+        'stock',
         'status',
         'SKU',
     ]
diff --git a/InvenTree/stock/migrations/0068_stockitem_serial_int.py b/InvenTree/stock/migrations/0068_stockitem_serial_int.py
new file mode 100644
index 0000000000..874978dc61
--- /dev/null
+++ b/InvenTree/stock/migrations/0068_stockitem_serial_int.py
@@ -0,0 +1,18 @@
+# Generated by Django 3.2.5 on 2021-11-09 23:30
+
+from django.db import migrations, models
+
+
+class Migration(migrations.Migration):
+
+    dependencies = [
+        ('stock', '0067_alter_stockitem_part'),
+    ]
+
+    operations = [
+        migrations.AddField(
+            model_name='stockitem',
+            name='serial_int',
+            field=models.IntegerField(default=0),
+        ),
+    ]
diff --git a/InvenTree/stock/migrations/0069_auto_20211109_2347.py b/InvenTree/stock/migrations/0069_auto_20211109_2347.py
new file mode 100644
index 0000000000..f4cdde7794
--- /dev/null
+++ b/InvenTree/stock/migrations/0069_auto_20211109_2347.py
@@ -0,0 +1,54 @@
+# Generated by Django 3.2.5 on 2021-11-09 23:47
+
+import re
+
+from django.db import migrations
+
+
+def update_serials(apps, schema_editor):
+    """
+    Rebuild the integer serial number field for existing StockItem objects
+    """
+
+    StockItem = apps.get_model('stock', 'stockitem')
+
+    for item in StockItem.objects.all():
+
+        if item.serial is None:
+            # Skip items without existing serial numbers
+            continue
+
+        serial = 0
+
+        result = re.match(r"^(\d+)", str(item.serial))
+
+        if result and len(result.groups()) == 1:
+            try:
+                serial = int(result.groups()[0])
+            except:
+                serial = 0
+
+
+        item.serial_int = serial
+        item.save()
+
+
+def nupdate_serials(apps, schema_editor):
+    """
+    Provided only for reverse migration compatibility
+    """
+    pass
+
+
+class Migration(migrations.Migration):
+
+    dependencies = [
+        ('stock', '0068_stockitem_serial_int'),
+    ]
+
+    operations = [
+        migrations.RunPython(
+            update_serials,
+            reverse_code=nupdate_serials,
+        )
+    ]
diff --git a/InvenTree/stock/models.py b/InvenTree/stock/models.py
index 320807e0c1..8e07074a76 100644
--- a/InvenTree/stock/models.py
+++ b/InvenTree/stock/models.py
@@ -7,6 +7,7 @@ Stock database model definitions
 from __future__ import unicode_literals
 
 import os
+import re
 
 from django.utils.translation import gettext_lazy as _
 from django.core.exceptions import ValidationError, FieldError
@@ -223,6 +224,32 @@ class StockItem(MPTTModel):
         self.scheduled_for_deletion = True
         self.save()
 
+    def update_serial_number(self):
+        """
+        Update the 'serial_int' field, to be an integer representation of the serial number.
+        This is used for efficient numerical sorting
+        """
+
+        serial = getattr(self, 'serial', '')
+
+        # Default value if we cannot convert to an integer
+        serial_int = 0
+
+        if serial is not None:
+
+            serial = str(serial)
+
+            # Look at the start of the string - can it be "integerized"?
+            result = re.match(r'^(\d+)', serial)
+
+            if result and len(result.groups()) == 1:
+                try:
+                    serial_int = int(result.groups()[0])
+                except:
+                    serial_int = 0
+
+        self.serial_int = serial_int
+
     def save(self, *args, **kwargs):
         """
         Save this StockItem to the database. Performs a number of checks:
@@ -234,6 +261,8 @@ class StockItem(MPTTModel):
         self.validate_unique()
         self.clean()
 
+        self.update_serial_number()
+
         user = kwargs.pop('user', None)
 
         # If 'add_note = False' specified, then no tracking note will be added for item creation
@@ -504,6 +533,8 @@ class StockItem(MPTTModel):
         help_text=_('Serial number for this item')
     )
 
+    serial_int = models.IntegerField(default=0)
+
     link = InvenTreeURLField(
         verbose_name=_('External Link'),
         max_length=125, blank=True,
diff --git a/InvenTree/templates/js/translated/stock.js b/InvenTree/templates/js/translated/stock.js
index ec785969cd..ba4238e6f7 100644
--- a/InvenTree/templates/js/translated/stock.js
+++ b/InvenTree/templates/js/translated/stock.js
@@ -1128,7 +1128,9 @@ function loadStockTable(table, options) {
 
     col = {
         field: 'quantity',
+        sortName: 'stock',
         title: '{% trans "Stock" %}',
+        sortable: true,
         formatter: function(value, row) {
 
             var val = parseFloat(value);