diff --git a/invokeai/frontend/web/src/features/regionalPrompts/components/StageComponent.tsx b/invokeai/frontend/web/src/features/regionalPrompts/components/StageComponent.tsx
index 721ddf9d8e..83f589a392 100644
--- a/invokeai/frontend/web/src/features/regionalPrompts/components/StageComponent.tsx
+++ b/invokeai/frontend/web/src/features/regionalPrompts/components/StageComponent.tsx
@@ -1,5 +1,6 @@
 import { Flex } from '@invoke-ai/ui-library';
 import { useStore } from '@nanostores/react';
+import { createSelector } from '@reduxjs/toolkit';
 import { logger } from 'app/logging/logger';
 import { createMemoizedSelector } from 'app/store/createMemoizedSelector';
 import { useAppDispatch, useAppSelector } from 'app/store/storeHooks';
@@ -33,6 +34,11 @@ const selectSelectedLayerColor = createMemoizedSelector(selectRegionalPromptsSli
   return layer?.previewColor ?? null;
 });
 
+const selectSelectedLayerType = createSelector(selectRegionalPromptsSlice, (regionalPrompts) => {
+  const selectedLayer = regionalPrompts.present.layers.find((l) => l.id === regionalPrompts.present.selectedLayerId);
+  return selectedLayer?.type ?? null;
+});
+
 const useStageRenderer = (
   stage: Konva.Stage,
   container: HTMLDivElement | null,
@@ -47,6 +53,7 @@ const useStageRenderer = (
   const lastMouseDownPos = useStore($lastMouseDownPos);
   const isMouseOver = useStore($isMouseOver);
   const selectedLayerIdColor = useAppSelector(selectSelectedLayerColor);
+  const selectedLayerType = useAppSelector(selectSelectedLayerType);
   const layerIds = useMemo(() => state.layers.map((l) => l.id), [state.layers]);
   const renderers = useMemo(() => (asPreview ? debouncedRenderers : normalRenderers), [asPreview]);
   const dpr = useDevicePixelRatio({ round: false });
@@ -135,6 +142,7 @@ const useStageRenderer = (
       stage,
       tool,
       selectedLayerIdColor,
+      selectedLayerType,
       state.globalMaskLayerOpacity,
       cursorPosition,
       lastMouseDownPos,
@@ -146,6 +154,7 @@ const useStageRenderer = (
     stage,
     tool,
     selectedLayerIdColor,
+    selectedLayerType,
     state.globalMaskLayerOpacity,
     cursorPosition,
     lastMouseDownPos,
diff --git a/invokeai/frontend/web/src/features/regionalPrompts/components/ToolChooser.tsx b/invokeai/frontend/web/src/features/regionalPrompts/components/ToolChooser.tsx
index 80ed271289..a3b556a7e5 100644
--- a/invokeai/frontend/web/src/features/regionalPrompts/components/ToolChooser.tsx
+++ b/invokeai/frontend/web/src/features/regionalPrompts/components/ToolChooser.tsx
@@ -1,16 +1,27 @@
 import { ButtonGroup, IconButton } from '@invoke-ai/ui-library';
 import { useStore } from '@nanostores/react';
+import { createSelector } from '@reduxjs/toolkit';
 import { useAppDispatch, useAppSelector } from 'app/store/storeHooks';
-import { $tool, selectedLayerDeleted, selectedLayerReset } from 'features/regionalPrompts/store/regionalPromptsSlice';
+import {
+  $tool,
+  selectedLayerDeleted,
+  selectedLayerReset,
+  selectRegionalPromptsSlice,
+} from 'features/regionalPrompts/store/regionalPromptsSlice';
 import { useCallback } from 'react';
 import { useHotkeys } from 'react-hotkeys-hook';
 import { useTranslation } from 'react-i18next';
 import { PiArrowsOutCardinalBold, PiEraserBold, PiPaintBrushBold, PiRectangleBold } from 'react-icons/pi';
 
+const selectIsDisabled = createSelector(selectRegionalPromptsSlice, (regionalPrompts) => {
+  const selectedLayer = regionalPrompts.present.layers.find((l) => l.id === regionalPrompts.present.selectedLayerId);
+  return selectedLayer?.type !== 'masked_guidance_layer';
+});
+
 export const ToolChooser: React.FC = () => {
   const { t } = useTranslation();
   const dispatch = useAppDispatch();
-  const isDisabled = useAppSelector((s) => s.regionalPrompts.present.layers.length === 0);
+  const isDisabled = useAppSelector(selectIsDisabled);
   const tool = useStore($tool);
 
   const setToolToBrush = useCallback(() => {
diff --git a/invokeai/frontend/web/src/features/regionalPrompts/util/renderers.ts b/invokeai/frontend/web/src/features/regionalPrompts/util/renderers.ts
index 944d996bff..2e437728b5 100644
--- a/invokeai/frontend/web/src/features/regionalPrompts/util/renderers.ts
+++ b/invokeai/frontend/web/src/features/regionalPrompts/util/renderers.ts
@@ -133,6 +133,7 @@ const renderToolPreview = (
   stage: Konva.Stage,
   tool: Tool,
   color: RgbColor | null,
+  selectedLayerType: Layer['type'] | null,
   globalMaskLayerOpacity: number,
   cursorPos: Vector2d | null,
   lastMouseDownPos: Vector2d | null,
@@ -144,6 +145,9 @@ const renderToolPreview = (
   if (layerCount === 0) {
     // We have no layers, so we should not render any tool
     stage.container().style.cursor = 'default';
+  } else if (selectedLayerType !== 'masked_guidance_layer') {
+    // Non-mask-guidance layers don't have tools
+    stage.container().style.cursor = 'not-allowed';
   } else if (tool === 'move') {
     // Move tool gets a pointer
     stage.container().style.cursor = 'default';